https://www.walmart.com/ip/Popsicle-Rainbow-Big-Stick-3-5-oz/198225061 POPSICLE- a software suite to determine population structure and to establish genotype-phenotype associations using Next-generation sequencing data niaidlogo





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POPSICLE Package  

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Used Case

Generate necessary files to draw circos plots
Prerequisites
  1. Find the local ancestries using the utility POPSICLEIntermediate, polished using the utility PolishPopsicle and arranged using the utility ArrangePopsicleByClustersFormed
What does it do?
It generates files required to draw circos plots
How to run it?
java -jar LPDtools.jar ConvertPopsicle2CircosHighlights -i polishedArrangedAncestryFile -o outputDirectory -j PopsicleBaselineFile -k clustersFile



Here, -i is the ancestry file generated using the utility POPSICLEIntermediate , polished using the utility PolishPopsicle and arranged using the utility ArrangePopsicleByClustersFormed. -k is the clusters file generated using the utility PerformKmeansClustering and -j is the baseline file generated using the utility FindDivergenceFromBaseline utility of POPSICLE
Output
circos
Outer concentric circle is local ancestries, middle concentric circle is global ancestries and inner concentric circle is clade assignment of the sample. Links demonstrate similarities between the clades

CITATION: Jahangheer S. Shaik, Asis Khan and Michael E. Grigg, "POPSICLE: A Software Suite to Study Population Structure and Ancestral Determinants of Phenotypes using Whole genome Sequencing Data", submitted to PLoS special edition